Car T Cell Therapy Side Effects

When the modified t cells kill the tumor cells these then break into component parts and all the leftover gunk can be floating in your bloodstream.

Car t cell therapy side effects.

Neurologic events can also be experienced and can be serious in some patients. A potentially serious complication is cytokine release syndrome crs also known as a cytokine storm. Serious side effects of this release can include very high fevers and dangerously low blood pressure in the days after treatment is given. Cytokines are immune substances that have many different functions in the body.

This happens when car t cells begin attacking cancer and trigger an. Low white blood. Cytokine release syndrome crs. Car t cell therapy can cause a serious side effect known as cytokine release syndrome.

The most common side effects seen are. As car t cells multiply they cause massive amounts of chemicals called cytokines to be released into the blood. Car t cell therapy side effects. Some people have had serious side effects from this treatment especially as the car t cells multiply in the body to fight the cancer.

The 133 participants in the fred hutch clinical trial believed to be the largest sample size in any published study of car t cell therapy side effects had advanced leukemias or lymphomas that had proven resistant to standard therapies. Neurologic events include encephalopathy. Cytokine release syndrome which is similar to flu like symptoms headache. Because it s affecting your immune system car t can cause other changes in your body too.

Again tumor lysis is a side effect showing that the car t cell treatment is working perhaps too well. While the therapy can lead to long lasting remissions for some patients with very advanced cancer it can also cause neurologic side effects such as speech problems tremors delirium and seizures. Despite the therapeutic successes of car t cell therapy the intervention carries the risk of severe side effects. Car t cell therapy can trigger a range of side effects many of which begin subtly but can rapidly worsen.

These include neurotoxicity which can result in headache confusion and. Cytokine release syndrome crs you may have heard of the cytokine storm in 2018 when many people got seriously ill during flu season.